Animal research is not always king: researchers should explore the alternatives. Nature 631, 481 (2024). doi: https://doi.org/10.1038/d41586-024-02314-8
Choi, Se Hoon ; Kim, Young Hye; Hebisch, Matthias; Sliwinski, Christopher; Lee, Seungkyu; D’Avanzo, Carla; Chen, Hechao; Hooli, Basavaraj; Asselin, Caroline; Muffat, Julien; Klee, Justin B.; Zhang, Can; Wainger, Brian J.; Peitz, Michael; Kovacs, Dora M.; Woolf, Clifford J.; Wagner, Steven L.; Tanzi, Rudolph E. & Kim, Doo Yeon (2014): A three-dimensional human neural cell culture model of Alzheimer’s disease.
Engelhardt, J.A., 2008. Predictivity of animal studies for human injection side reactions with parenteral drug products. Exp. Toxicol. Pathol. 60 (4-5), 323-7.
Fink, M. P. (2014). Animal models of sepsis, Virulence, 5:1, 143-153, DOI:10.4161/viru.26083
Hartung, T., 2009. Toxicology for the twenty-first century. Nature 460, 208-212.
Leist, M. & Hartung, T. (2013): Inflammatory findings on species extrapolations: humans are definitely no 70-kg mice. Arch. Toxicol. 87: 563-567.
Olson, H., Betton, G., Robinson, D., Thomas, K., Monro, A., Kolaja, G., Lilly, P., Sanders, J., Sipes, G., Bracken, W., Dorato, M., Van Deun, K., Smith, P., Berger, B., Heller, A., 2000. Concordance of the toxicity of pharmaceuticals in humans and in animals. Regul. Toxicol. Pharmacol. 32(1), 56-67.
Shanks, N., Greek, R., Greek, J., 2009. Are animal models predictive for humans? Philos. Ethics Humanit. Med. 15, 4:2.
Sistare, F.D., DeGeorge, J.J., 2007. Preclinical Predictors of Clinical Safety: Opportunities for Improvement. Clin. Pharmacol. Ther. 82, 210-214.