Scientists from the University of Ulm led by Prof. Marcus Fändrich from the Institute of protein biochemistry and colleagues from Tübingen, Halle (Saale) and San Diego, extracted beta amyloid fibrils from tissue samples of diseased humans and precisely described them. They found out, that the fibers differ significantly from those synthetic fibrils used for in vitro research. Both the peptide shape and the twist shape are different than previously assumed. This also means that they have other properties.

For further in vitro research, it is now necessary to find ways and methods that will lead to the development of new artificial fibrils to reproduce the discovered form.

The scientists have published their findings in the journal Nature Communications:
Marius Kollmer, William Close, Leonie Funk, Jay Rasmussen, Aref Bsoul, Angelika Schierhorn, Matthias Schmidt, Christina J. Sigurdson, Mathias Jucker & Marcus Fändrich (2019). Cryo-EM
structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer's brain tissue. Nature Communications 10, Article number: 4760.

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