The liver-on-a-chip model consists of human hepatocytes, which are the actual chemical factory in of the liver, endothelial cells of the sinusoids, which are also metabolically active, as well as Kupffer cells, which belong to the immune system as macrophages, and star cells (Ito cells), which become active during repair work and, in the case of illness, are involved in the reconstruction to a connective tissue up to a liver cirrhosis.
The examination was successful. The scientist and her team were able to recognize that an endothelin receptor antagonist called bosentan, which is approved for the treatment of pulmonary arterial disease, damages the liver cells. One of the serious side effects is bile congestion, triggered by inhibition of a bile salt pump on the hepatocytes.
This complication was not detected in rats or dogs in animal studies.
Source:
https://www.aerzteblatt.de/nachrichten/107276/Leber-Chip-erkennt-Hepatotoxizitaet-von-Arzneimitteln?rt=8b1a674cf080a3174d3d19d876630244
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Thursday, 28 November 2019 21:10
Liver-on-a-Chip reliably detects liver-toxicity of drugs Featured
Using a liver-on-a-chip model, a team led by Dr. Geraldine Hamilton, scientific director of the start-up company Emulate from Boston, has investigated whether they are able to detect the toxicity of drugs at an early stage.
Dr. rer. nat.
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