Scientists of the Paul Ehrlich Institute have worked together with colleagues from the Medical University of Hannover and from France to develop induced pluripotent stem cells (iPSCs) of a healthy person, a patient with Aicardi-Goutières syndrome as well as from a patient with Renpenning syndrome. In these diseases, proteins play a role that is also important for the immunological recognition of the human immunodeficiency virus (HIV). With iPSCs and derived cell types, new insights into the syndromes and the human immune system in the fight against HIV can be won.
The journal Stem Cell Research reports on the results of this research in three articles, published in the December 2019 and January 2020.
Further information:
https://www.pei.de/DE/newsroom/pm/jahr/2020/02-pluripotente-stammzellen-erforschung-hiv.html