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Wednesday, 02 December 2020 15:16

Corona particles in the olfactory mucosa Featured

A research team from Charité-Universitätsmedizin Berlin, Humboldt University Berlin, and other scientists* has succeeded in detecting the Sars-Cov2 virus in neuroanatomical structures that connect the eye, mouth, and nose with the brain stem. Using special staining and electron microscopic imaging, they were able to visualize and photograph intact coronavirus particles in the olfactory mucosa, where the virus was most commonly found.


A research team consisting of neuropathologists, pathologists, forensic doctors as well as virologists from the Charité - Universitätsmedizin Berlin and other institutions led by Prof. Dr. Frank Heppner analyzed tissue samples from deceased COVID-19 patients. They wanted to find out in which way the novel coronavirus can enter the brain and how the immune system reacts to the virus there.

They reconstructed that SARS-CoV-2 enters the brain via the nerve cells of the olfactory mucosa.

The research team published their work in Nature Neuroscience:
Meinhardt J et al.(2020). Olfactory transmucosal SARS-CoV-2 invasion as port of central nervous system entry in individuals with COVID-19 Nat Neurosci 2020. doi: 10.1038/s41593-020-00758-5
 
Source:
https://www.charite.de/service/pressemitteilung/artikel/detail/wie_sars_cov_2_in_das_gehirn_gelangt/