A so-called "generic strategy" will be worked out for the development of New Approach Methods (NAMs) without animal testing, which later can be applied to any type of chemical toxicity effects of pharmaceuticals, cosmetics, food, or biocides by repeated administration.

The project participants have six specific NAMs in mind: those for the liver (steatosis and cholestasis), the kidneys (tubular necrosis and crystallopathy), as well as the developing brain (neural tube occlusion and cognitive dysfunction).

The individual NAMs will consist of computer systems, which in turn will be based on state-of-the-art artificial intelligence. The data basis will be based on available biological/mechanistic, toxicological/epidemiological, physicochemical, and kinetic information. If data gaps are identified by AI, they are closed with targeted in vitro and in silico tests.

17 institutions (universities, start-ups or SMEs) are involved. The European Union is providing a total of €17,211,050 for the project. The duration
is five years. The coordinator is the Vrije Universiteit Brussel.

More information:
https://cordis.europa.eu/project/id/963845?mc_cid=d9c62141ef&mc_eid=6733e47126