The team led by Marianna Kruithof-de Julio from the Department for BioMedical Research (DBMR) of the University of Bern and Inselspital Bern has taken prostate cancer biopsies and generated organoids from the isolated cancer cells. The characteristics of the organoids are similar to the original tumor, showing the same genetic mutations and similar gene activity patterns.
Out of 74 different drugs, one agent proved to be particularly suitable, which has so far only been approved for the treatment of leukemias.
Original publication:
Karkampouna, S., La Manna, F., Benjak, A. et al. Patient-derived xenografts and organoids. model therapy response in prostate cancer. Nat Commun 12, 1117 (2021). https://doi.org/10.1038/s41467-021-21300-6
Source:
https://www.unibe.ch/
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Tuesday, 16 March 2021 13:22
Bern: Organoids lead to better treatment of prostate cancer Featured
Researchers at the University of Bern and at Inselspital Bern have cultivated so-called prostate organoids and successfully tested their efficacy with various drugs. In this way, it is possible to determine which therapy is most likely to benefit patients before starting treatment.
Dr. rer. nat.
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