Cystic fibrosis is an inherited metabolic disease that causes symptoms in early childhood and is chronically progressive.
The in vitro model replicates CF-specific changes in the disease, including those in the mucus layer of the airways, beating of the mucus-transporting cilia, growth of pathogens, inflammatory molecules, and in the recruitment of white blood cells.
The development thus represents a comprehensive preclinical human model for exploring new therapies for cystic fibrosis.
Source:
https://wyss.harvard.edu/
More about Cystic Fibrosis:
https://www.cff.org/intro-cf/about-cystic-fibrosis
-
font size
decrease font size
increase font size
Wednesday, 01 December 2021 12:48
Wyss Institute: new in vitro model to study cystic fibrosis Featured
A research team at the Harvard Wyss Institute for Biologically Inspired Engineering led by Donald Ingber, M.D., Ph.D., has developed a microfluidic organ chip device that is about the size of a USB memory stick, which more accurately reproduces the key pathological features of cystic fibrosis (CF) than other in vitro systems.
Dr. rer. nat.
Menschen für Tierrechte - Tierversuchsgegner Rheinland-Pfalz e.V.