The research team from the Berlin Institute of Health at the Charité (BIH), the Charité - Universitätsmedizin Berlin as well as from the University Hospitals in Bonn and Aachen examined the blood of COVID-19 patients with mild or severe progression using single-cell analysis and compared the results with those of healthy volunteers and patient blood with other viral infections.
They found T cells in the people severely affected by COVID-19 that carried the molecule CD16 on their surface. CD16 normally helps cells of the innate immune system recognize and kill virus-infected body cells. In contrast, T cells normally recognize virus-infected cells via their T cell receptor. Using the mechanism now discovered, these T cells are able to fight not only specifically virus-infected cells, but also healthy vascular cells.
Original publication:
Georg, P., Astaburuaga-Garcia, R., Bonaguro, L., et al: (2021). Complement activation induces excessive T cell cytotoxicity in severe COVID-19. Cell,
DOI: 10.1016/j.cell.2021.12.040
Source and further information:
https://www.bihealth.org/de/aktuell/die-fatale-rolle-der-t-zellen-bei-covid-19