The study included subjects from the TUM's Klinikum Rechts der Isar who had been regularly examined since the beginning of the pandemic. One group of participants had become infected with SARS-CoV-2 in spring 2020, the second group had not. Later, both groups received the COVID-19 vaccine from Biontech/Pfizer and the volunteers were followed up for two years.
The team led by Prof. Ulrike Protzer of the Institute of Virology at the Technical University of Munich examined in the participants' blood the amount of antibodies (IgG), the strength of binding between viral protein and antibody, and the ability of antibodies to neutralize SARS-CoV-2 variants in cell culture.
The study was published in Nature Medicine:
Wratil, P.R., Stern, M., Priller, A. et al. Three exposures to the spike protein of SARS-CoV-2 by either infection or vaccination elicit superior neutralizing immunity to all variants of concern. Nat Med (2022). https://doi.org/10.1038/s41591-022-01715-4
Source and further information:
https://www.tum.de/die-tum/aktuelles/covid-19/artikel/37162
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Thursday, 03 February 2022 14:16
SARS-Cov-2: All good things come in threes Featured
Researchers at the Technical University of Munich have discovered that a total of three contacts to the spike protein as a viral antigen are necessary for neutralizing antibodies to be formed not only in sufficient quantity but also in high quality. The quality also helps against the omicron variant.
Dr. rer. nat.
Menschen für Tierrechte - Tierversuchsgegner Rheinland-Pfalz e.V.