The retinal organoids were developed from human induced pluripotent stem cells by postdoctoral researcher Dr. Yotam Menuchin-Lasowski. The researchers, led by Dr. Thomas Rauen and Prof. Hans Schöler of the Max Planck Institute for Molecular Biomedicine as well as virologist Prof. Stephan Ludwig of the Westphalian Wilhelm University of Münster, have used the organoids to find out by quantitative PCR analysis that Sars-CoV-2 does indeed primarily infect retinal ganglion cells and light-sensing cells. In addition, they were able to show by fluorescence microscopy that the coronaviruses can also replicate themselves in these cell types.
Original publication:
Yotam Menuchin-Lasowski , André Schreiber , Aarón Lecanda, Angeles Mecate-Zambrano, Linda Brunotte, Olympia E. Psathaki, Stephan Ludwig, Thomas Rauen & Hans R. Schöler (2022). SARS-CoV-2 infects and replicates in photoreceptor and retinal ganglion cells of human retinal organoids. Stem Cell Reports, April 12, 2022, online advance publication March 24, 2022. https://www.biorxiv.org/content/10.1101/2021.10.09.463766v1
Read more here:
https://www.mpg.de/18451525/0322-vasb-sars-cov-2-geht-ins-auge-154090-x