They were able to prove that after the hepatitis E virus has invaded the liver, infected liver cells secrete a viral protein that reacts with antibodies in the blood - and as a complex can damage the filtering devices in the kidneys.

Original publication:
Leblond AL, Helmchen B, Ankavay M, Lenggenhager D, Jetzer J, Helmchen F, Yurtsever H, Parrotta R, Healy ME, Pöschel A, Markkanen E, Semmo N, Ferrié M, Cocquerel L, Seeger H, Hopfer H, Müllhaupt B, Gouttenoire J, Moradpour D, Gaspert A, Weber A. HEV ORF2 protein-antibody complex deposits are associated with glomerulonephritis in hepatitis E with reduced immune status. Nat Commun. 2024 Oct 14;15(1):8849. doi: 10.1038/s41467-024-53072-0. PMID: 39397005; PMCID: PMC11471813.

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