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The OECD has published a new test guideline. It describes several defined approaches to classify skin sensitization potential that are equivalent or even superior to the information provided by the mouse Local Lymph Node Assay.

After twelve months of preparation, the new Einstein Center for Alternative Methods in Biomedical Research will officially be launched this week.

A team of scientists at the Institute of Molecular Biotechnology (IMBA) of the Austrian Academy of Sciences has developed cardioids, which are self-organizing heart organoids, from induced pluripotent stem cells.

An interdisciplinary team led by the Innsbruck immunologists Professor Doris Wilflingseder and Associate Professor Dr. Wilfried Posch has succeeded in using an in vitro model to identify the drivers of the excessive immune response in COVID-19 infection.

Once again, the Senate Department for Justice, Consumer Protection and Anti-Discrimination, the State Office for Health and Social Affairs (LaGeSo) as well as the Association of Research-Based Pharmaceutical Companies (vfa) are offering the "Alternatives to Animal Testing" research prize of the State of Berlin to promote the development of replacement and supplementary methods.

Using cell cultures, scientists at the Paul-Ehrlich-Institut and the Marburg University Hospital have investigated the interactions between retrotransposons and the hepatitis C virus (HCV). They found that HCV infection can restrict human LINE-1 retrotransposition into cells.

Scientists from the Institute of Molecular Virology at the University of Ulm, Germany, have studied in vitro how the SARS-Cov-2 virus paralyzes the immune system by shutting down antiviral signaling pathways.

Using in vitro cell cultures, scientists from the Translational Genomics Research Institute (TGen) in Phoenix, Arizona, have shown that the blood-brain barrier ABC transporter ABCC1 is not only capable of exporting the feared amyloid-ß from the cytoplasm of human cells. Its overexpression can even significantly reduce amyloid-ß production.

Researchers at Johannes Gutenberg University Mainz (JGU) and at the Institute of Molecular Biology of Barcelona have used insect cells to study an important function of two enzymes that may play a role in Alzheimer's disease. They visualized their findings with a computer model.

Using a 3D printer, scientists from the Picower Institute for Learning and Memory at MIT and the Indian Institute of Technology Madras have created a new microfluidic system with a bioreactor made from a dental building material that is very inexpensive and also reusable.