Docosahexaenoic acid (DHA) is an omega-3 fatty acid. In transgenic mouse model studies have shown that omega-3 fatty acid consumption can reduce Alzheimer disease risk. An examinations with Alzheimer patients DHA did not slow the rate of cognitive and functional decline of brain.

The Directive will enter into force on 9th Nov. 2010. Using animals should only be considered where a non-animal alternative is unavailable. To promote the principle of reduction, Member States should facilitate the establishment of programmes for sharing organs and tissues. Availability of alternative methods is dependent on the progress of the research into the development of alternatives. There is an increasing need for new methods to be developed and proposed for validation. Community programmes provide increasing funding for projects which aim to replace, reduce and refine the use of animals.

Harvard bioengineers have been awarded $3.3 million in funding from the National Institutes of Health and the U.S. Food and Drug Administration (NIH-FDA) to develop a "Heart-Lung Micromachine". The device will accelerate drug safety and efficacy testing.

The Congress Linz 2010, this year the major international scientific event in the field of the 3Rs, took place on 2nd – 4th September in Linz, Austria. The congress was held as a joint congress of the European Society for Toxicology In Vitro (ESTIV) and the European Society for Alternatives to Animal Testing (EUSAAT). It was therefore the 16th International Congress on In Vitro Toxicology, the 13th Annual Congress of EUSAAT and the 16th Congress on Alternatives to Animal Testing.

A group of researchers, funded by the European Comission, published in the actual issue of „Reproductive Toxicology“ a study, the so called "Feasibility Study" within the project ReProTect, in which they determine the hurtful effects of chemicals on reproduction reliably with animal-free methods.

An animal-free method has been included in the OECD test guideline (439 In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method) on July, 22. This method now is approved by the authorities and has world-wide validity. With implementation of this in vitro test the amount of rabbits killed is expected to decrease significantly.

A microfluidic platform on which fragile blood vessels can be fixed was recently developed by Canadian scientists. The device allows to study the factors that promote and sustain cardiovascular diseases. The device could be used to routinely screen drug candidates on viable arteries. This may speed up the drug development process and could reduce animal experimentation.

We are very pleased to have listed over 85 state-of-the-art research groups and companies on our list of working groups. These groups mainly apply or even develop non-animal research methods.

A team of researchers at Columbia Engineering School has developed a new technique to evaluate human stem cells using cell micropatterning — a simple but powerful in vitro tool that will enable scientists to study the initiation of left-right asymmetry during tissue formation, to diagnose disease, and to study factors that could lead to certain birth defects.

Donald E. Ingber, Harward Univ., Boston (MA/USA), and colleagues have created a device that mimics a human lung on a microchip by using human lung and blood vessel cells and combining microfabrication techniques from the computer industry with modern tissue engineering techniques. The ability of the device to predict absorption of airborne nanoparticles and mimic the inflammatory response triggered by microbial pathogens, is a further proof for the concept that „organs-on-chips“ could replace many animal studies.