SARS-Cov-2 can invade the brain

Tuesday, 08 February 2022 11:57

Using brain capillary endothelial cells from induced pluripotent stem cells of deceased Covid-19 patients, a team of researchers from Hamburg, Kiel, Würzburg, Vienna, and the United States has shown that SARS-CoV-2 can enter the brain across the blood-brain barrier, leading to increased interferon signaling.

Gabriel Salg, Scientific Project Manager at the Department of Surgery at Heidelberg University Hospital (UKHD), along with his team, is working on an artificially created pancreas produced in a 3D printer. They want to be able to supply patients with a new "organ" in the future.

SARS-Cov-2: All good things come in threes

Thursday, 03 February 2022 14:16

Researchers at the Technical University of Munich have discovered that a total of three contacts to the spike protein as a viral antigen are necessary for neutralizing antibodies to be formed not only in sufficient quantity but also in high quality. The quality also helps against the omicron variant.

Using brain organoids, scientists at the Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA) in Vienna have found that the cause of a rare neurodevelopmental disorder, tuberous sclerosis, is exclusively rooted in the biology of the human brain.

Omicron: A weak point found

Tuesday, 25 January 2022 14:36

Using human cell cultures, a German-British research team succeeded in showing that omicron viruses are less effective than delta viruses in inhibiting the cell's own immune response by the messenger interferon. This may contribute to the observed lower pathogenicity of the omicron variant in patients.

The Foundation to Promote Cancer Research at the Julius Maximilians University of Würzburg (JMU) supports cancer research projects using state-of-the-art methods. Among other things, the development of a personalized in vitro tumor model is planned, and signaling pathway analyses, machine learning methods, as well as artificial intelligence, will be used.

Researchers from the Organo-Lab at the University of Tübingen, Germany, have developed an immuno-competent choroid on-chip model based on human cells. The model enables the study of drug-induced toxicity reactions in the eye or inflammatory diseases of the choroid such as uveitis and wet age-related macular degeneration.

An international team of researchers led by the University of Cambridge has discovered new findings on the development of Alzheimer's disease in a patient study.

A team of researchers led by the Paul Ehrlich Institute has studied the interaction between the Zika virus and the antiviral restriction factor tetherin.

Reproductive crisis in cancer research

Sunday, 09 January 2022 13:46

Eight years ago, the Reproducibility Project: Cancer Biology (RP: CB) was started. The goal was to replicate the results of top cancer laboratories. Looking at high-ranking research articles from 2010 and 2012, the team has now come to a sobering conclusion: The reproducibility of the work is less than 50%.