Working group - a Portrait (20)

InVitro+Jobs regularly presents scientists and their innovative research in the form of a "Working Group - a Portrait". It focuses on newly developed methods, their evaluation, and the outlook on which animal experimental approaches can be reduced and at best replaced according to the 3R principle (reduce, refine, replace).

InVitro+Jobs regularly presents scientists and their innovative research as "Working Group - a Portrait". The focus is on newly developed methods, their evaluation, and the prospect of which animal experimental approaches could be reduced and ideally replaced following the 3R principle (reduce, refine, replace).

In this issue, we present the start-up Hesperos from Orlando in Florida, USA. Hesperos develops pumpless microphysiological multi-organ systems (human-on-a-chip systems) that can be used not only in toxicity testing and drug development but also for research into rare diseases.

InVitro+Jobs presents scientists and their innovative research in a regular feature called “Working Group – a Portrait”. We focus on newly developed methods, their evaluation, and their potential for reducing and where possible replacing animal experimentation according to the 3R principles of Russel & Burch (reduce, refine, replace).
In this issue, we present a young spin-off from Jena, Dynamic42 GmbH. The company was founded in March 2018 as a spin-off from the "Center of Sepsis Control and Care" (CSCC) of the University Hospital Jena, Germany.

InVitro+Jobs regularly presents scientists and their innovative research. The focus is on newly developed methods, their evaluation as well as the perspectives, which animal experimental approaches can be reduced - or better - replaced according to the 3R principle (reduce, refine, replace). In this issue we focus on reproduction and developmental toxicology.

Reproduction and developmental toxicology without animal experiments:
Where do we stand with science?


This time we do not present a single group as usual because research questions that have been answered with countless animals so far are too wide-ranging. The animals cannot be replaced by separate new methods. Lots of groups are working on individual new methods. Conclusion: A replacement of animal experiments can only succeed if many individual methods are integrated in a test strategy.

InVitro+Jobs presents scientists and their innovative research in a regular feature called “Working Group – a Portrait”. We focus on newly developed methods, their evaluation and their potential for reducing and where possible replacing animal experimentation according to the 3R principles of Russel & Burch (reduce, refine, replace).
In this issue we present the Department “Drug Delivery” at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) headed by Prof. Dr. Claus-Michael Lehr, Professor for Biopharmaceutics and Pharmaceutical Technology at Saarland University.

InVitro+Jobs presents scientists and their innovative research in a regular feature called “Working Group – a Portrait”. We focus on newly developed methods, their evaluation and their potential for reducing and where possible replacing animal experimentation according to the 3R principles of Russel & Burch (reduce, refine, replace).

 

Working group – a Portrait:
IfADo – Leibniz Research Centre for Working Environment and Human Factors,
Department of Toxicology, Research Group Systems Toxicology


The IfADo – Leibniz Research Centre for Working Environment and Human Factors in Dortmund is a research institute, where scientists investigate the growing challenges in the working environment in the face of an increasingly ageing population (ergonomics), regarding the part played by the immune system with regard to infections and cancer (immunology), the part played by the cerebral cortex and neuroplasticity in experiencing, behaviour, learning and memory formation (psychology and neurosciences), and with toxicology, investigating the toxic processes caused by chemicals in the liver or the nervous system (1).

InVitro+Jobs presents scientists and their innovative research in a regular feature called “Working Group – a Portrait”. We focus on newly developed methods, their evaluation and their potential for reducing and where possible replacing animal experimentation according to the 3R principles of Russel & Burch (reduce, refine, replace).

In this feature we present an institute that amongst other things researches the development of in vitro disease models (“diseases in a dish”). The models allow to study of disease developments based on patient-specific human cells instead on genetic modified animals (animal models).

InVitro+Jobs presents scientists and their innovative research in a regular feature called “Working Group – a Portrait”. We focus on newly developed methods, their evaluation and their potential for reducing and where possible replacing animal experimentation according to the 3R principles of Russel & Burch (reduce, refine, replace). In this edition we feature important research conducted by Prof. Dr. Gerhard Gstraunthaler, head of the working group „Renal Molecular Physiology “at the Medical University of Innsbruck.

InVitro+Jobs presents scientists and their innovative research in a regular feature called “Working Group – a Portrait”. We focus on newly developed methods, their evaluation and their potential for reducing and where possible replacing animal experimentation according to the 3R principles of Russel & Burch (reduce, refine, replace).


Working Group ‒ a Portrait: TissUse GmbH


This issue deals with highly topical research into and the development of minute organ-like cellular structures on a microchip, known as a “multi-organ chip”. The goal is use these platforms in order to replace substance testing on animals. Here we introduce the company TissUse.

InVitroJobs presents scientists and their innovative research in a regular feature called “Working Group – a Portrait”. We focus on newly developed methods, their evaluation and their potential for reducing and where possible replacing animal experimentation according to the 3R principles of Russel & Burch (reduce, refine, replace).

In this article we present an institute that researches the retention of organic substances in the environment and their evaluation. Head of the institute is the chemist Prof. Dr. Klaus Kümmerer. His research foci are sustainable chemistry, material resources and trace elements in the aquatic environment. Prof. Kümmerer looks for new properties for pharmaceuticals, with the goal of making them degradable in rivers and lakes. To this end the institute employs computer-based methods. A staff member also has the task of modelling and evaluating the global dispersion of harmful substances.

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