Quantitative Systems Pharmacology (QSP) models play a central and increasingly important role in clinical development. They combine biology, pharmacology, and mathematics to simulate the interactions between drugs and the complex human biological system on a computer.
Using a cellular assay, a British-Danish research team led by Prof. Holm H. Uhlig of the Centre for Human Genetics at the University of Oxford, UK, has confirmed that neutralizing autoantibodies can be responsible for chronic inflammatory bowel disease in certain cases.
On June 15, the National Institutes of Health (NIH) announced the establishment of the “Office of Research Innovation, Validation, and Application” (ORIVA). ORIVA will coordinate NIH-wide efforts to develop, validate, and scale “New Approach Methodologies” (NAMs), including 3D models of human tissue, computer-based tools, and other animal-free methods that can better reflect human biology.
The Polish research and technology company QSAR Lab has developed the open-access database NAMs.network. The developers’ goal was to make knowledge about New Approach Methodologies (NAMs) for hazard characterization easier to find, understand, and use.
A German-American research team led by scientists from the Bernhard Nocht Institute for Tropical Medicine and the Icahn School of Medicine at Mount Sinai in New York has developed brain organoids to investigate the mechanisms that enable the feared Ebola virus to survive long-term in its host.
On June 10, 2026, Humane World for Animals organized an informational event at the European Parliament entitled “Funding for Non-Animal Science: A Moonshot for NAMs.” It was hosted by MEPs Cristina Guarda (Greens/EFA) and Sebastian Everding (The Left). The event was a roundtable discussion on financial support for the accelerated development, validation, and adoption of NAMs in biomedical research and safety testing.
As reported by the animal rights organization PETA, the “German Mouse Clinic” at Helmholtz Zentrum München has announced that it will no longer conduct the forced swim test. This is a major victory for animals.
Professor Dr. Christa Thöne-Reineke from the Free University of Berlin and Professor Dr. Birgit Schittek from the University of Tübingen are receiving this year’s Ursula M. Händel Animal Welfare Prize from the German Research Foundation (DFG). The prize is worth 80,000 euros. They will each receive an equal share of the prize.
On last Monday, the European Commission finally published the long-awaited roadmap for phasing out animal testing in chemical safety assessments. The announcement was accompanied by a three-day conference. The initiative is a result of the European Citizens’ Initiative “Save Cruelty-Free Cosmetics,” which received widespread public support across Europe for ending animal testing.
ECHA has established the Collaboration Platform for Alternatives to Animal Testing to support the development and adoption of alternative methods in a regulatory context within the scope of ECHA’s mandate. The platform aims to develop a common understanding of when and how alternative methods can be used to replace animal testing in the context of current information requirements.