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A team of researchers at Charité Berlin and the Max Delbrück Center for Molecular Medicine (MDC), led by private lecturer Dr. Michael Sigal, has discovered how SARS-CoV-2 uses the immune system to increasingly hijack mucosal cells of the body and multiply there. For their studies, they used intestinal organoids.

At Charité, a 15-year-old patient with a rare disease (Leigh syndrome - cardiomyopathy) has been treated therapeutically, after scientists worked on a personalized in vitro disease model to find a suitable drug.

In a new Bavarian network, a team from Würzburg University Hospital is researching the effects of ultra-fine dust. For this purpose, complex cell culture models from the human nasal mucosa are used.

Using cell cultures, researchers at the University of Veterinary Medicine Hanover (TiHo) have investigated how porcine pestiviruses penetrate the cells of their hosts.

On May 1, the EU project ONTOX will be launched.  It will develop a strategy to put an end to the long-term toxicity testing with animals (repeated dose toxicity).

With the help of cell cultures, a team of researchers at the Paul Ehrlich Institute (PEI) has investigated how the membrane fusion occurs after the spike protein has docked with the ACE2 receptor. Therefore, they have developed quantitative assays.

A test has been developed at the German Center for the Protection of Laboratory Animals (Bf3R) in Berlin that can detect hormone effects in cultured human cells. Using microscopy and artificial intelligence, the "E-Morph" test reliably finds substances that may have estrogen-like or even opposite (anti-estrogenic) effects.

Escherichia coli bacteria are naturally part of the human gut microbiome. However, some strains produce a toxin that is suspected of causing colorectal cancer. A team of researchers from Berlin has now been able to confirm this assumption in vitro.

Environmental toxicologists Prof. Henner Hollert and Dr. Andreas Schiwy from Goethe-University are developing alternatives to animal use for cell culture media. They have now received CRACK-IT innovation funding from the National Centre for the  Replacement, Refinement and Reduction of Animals in Research (NC3R).

Reutlingen: Tumor Interaction-on-a-Chip

Monday, 22 February 2021 10:41

The Natural and Medical Sciences Institute at the University of Tübingen (NMI), based in Reutlingen, is working with academic and industrial partners to develop a test system on a chip that simulates the interaction between tumor and immune system.

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