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Immune cell formation on the chip

Tuesday, 11 March 2025 12:09

A German-Israeli research team has developed an organ-on-a-chip model to study the development of human natural killer (NK) cells in the bone marrow.

Once again this year,  Doctors Against Animal Experiments (Ärzte gegen Tierversuche) is awarding the Herbert Stiller Prize for animal-free research. The association is committed to innovative human-based science and supports it with a grant of 20,000 euros made possible by sponsors. Research proposals can be submitted until 31 May 2025.

In order to develop effective drugs against pancreatic cancer, it is necessary to know about the interaction between tumor cells and the surrounding stroma. This is why in vitro models are important which can simulate precisely these interactions. A research team at Heinrich Heine University Düsseldorf led by Prof. Nicole Teusch in cooperation with the company Dynamic42 from Jena has succeeded in doing just that.

The conference on assessing the safety of chemicals without animal testing took place in Brussels at the beginning of March. It was organized by the European Commission together with the European Partnership for Alternatives to Animal Testing (EPAA). Participants included representatives from industry, regulatory authorities, NGOs and associations.

Researchers at the University of Bonn led by junior professor Elena Reckzeh, the company ESQlabs as well as the University Hospital Bonn want to refine treatment recommendations for colorectal cancer patients. For this purpose, intestinal organoids from patients are combined with the possibilities of digital twin technology.

A research team from Würzburg, Vienna, London and Switzerland have developed a geometric deep learning network called MARBLE, which helps to analyze thinking strategies of the human brain. MARBLE can recognize a common structure in the thinking of two individuals or species without ignoring the unique “language” of each brain.

Research teams from Würzburg and Braunschweig have discovered a novel mechanism of a protein that counteracts the CRISPR/Cas process. It can be used to specifically control CRISPR technologies.

The organ-on-a-chip developer Dynamic42 from Jena, ESQlabs, experts in digital solutions for life sciences, in close collaboration with Bayer's Consumer Health Division and the placental laboratory of the University Hospital Jena have successfully developed a three-organ system. The model has the potential to significantly reduce animal testing using organ-on-chip (OoC) technology and interactive computer software.

A European research team has developed an adipose tissue portal with molecular and clinical data from more than 6,000 women and men from 67 studies. The researchers want to facilitate research into obesity and metabolic diseases by centralizing and simplifying access to data on adipose tissue.

Prof. Frank Edenhofer, head of the Genomics, Stem Cell Biology and Regenerative Medicine research group at the University of Innsbruck, and his team have developed a human tissue model that can be used to watch the brain aging process.

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