Scientists from the Helmholtz Institute for RNA-based Infection Research (HIRI) Würzburg, the Julius-Maximilians-University Würzburg (JMU) and the Broad Institute (Cambridge, USA) have succeeded in creating the first global atlas of direct interactions between the SARS-CoV-2 RNA and the human host proteome. In addition, the authors identified key regulators of viral replication.

For their studies, the scientists infected human cells with the new coronavirus, which uses RNA as genetic material. In a second step, they purified the viral RNA and identified the proteins bound to it.

In total, the scientists identified 18 host proteins that play an important role during SARS-CoV-2 infection.

More information:
Schmidt N, Lareau C, Keshishian H, Ganskih S, Schneider C, Hennig T, Melanson R, Werner S, Wei Y, Zimmer M, Ade J, Kirschner L, Zielinski S, Dölken L, Lander ES, Caliskan N, Fischer U, Vogel J, Carr SA, Bodem J, Munschauer M; "The SARS-CoV-2 RNA-protein interactome in infected human cells"; Nature Microbiology; 2020.

Source:
https://www.bionity.com/de/news/1169305/wie-das-coronavirus-mit-zellen-interagiert.html