The model is constructed from the major cell types of the choroid, human melanocytes, retinal pigmented epithelial cells, and microvascular endothelial cells. These cells are integrated into a micro-physiological system simulating the structure of the choroid microvessels. The necessary immune cells are sent through the endothelial channel via tiny channels.
Original publication:
Cipriano, M., Schlünder, K., Probst, C. et al. Human immunocompetent choroid-on-chip: a novel tool for studying ocular effects of biological drugs. Commun Biol 5, 52 (2022). https://doi.org/10.1038/s42003-021-02977-3
Source:
http://www.loskill-lab.com/choroidchip.html
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Monday, 24 January 2022 21:46
Tübingen: Immuno-competent choroid on the chip Featured
Researchers from the Organo-Lab at the University of Tübingen, Germany, have developed an immuno-competent choroid on-chip model based on human cells. The model enables the study of drug-induced toxicity reactions in the eye or inflammatory diseases of the choroid such as uveitis and wet age-related macular degeneration.
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