As reported in Nature, it is characterized by the collective development of cells from different individual donors in a single organoid. Cells from several single donor organoids are reassembled at the stem cell or neural precursor cell stage and reaggregate then. The cells' properties are highly reproducible.

The scientists hope to be able to use the brain chimeric organoids to visualize individual differences in brain development and drug reactions. The aim of the researchers is to find individual differences in the susceptibility of the brain to disease. Instead of comparing this in several different organoids, in which other factors in the individual cultures could also play a role, they see an opportunity to detect the differences in one culture.

Original paper:
Antón-Bolaños N, Faravelli I, Faits T, Andreadis S, Kastli R, Trattaro S, Adiconis X, Wei A, Sampath Kumar A, Di Bella DJ, Tegtmeyer M, Nehme R, Levin JZ, Regev A, Arlotta P. Brain Chimeroids reveal individual susceptibility to neurotoxic triggers. Nature. 2024 Jun 26. doi: 10.1038/s41586-024-07578-8. Epub ahead of print. PMID: 38926573. https://www.nature.com/

For more information:
https://www.nature.com/articles/d41586-024-02096-z?utm_source=Live+Audience&utm_campaign=ef7ce33896-nature-briefing-daily-20240627&utm_medium=email&utm_term=0_b27a691814-ef7ce33896-50991200