Here, we provide information about carcinogenicity tests – tests to determine whether a substance can cause cancer or not. The knowledge is necessary to classify correctly, prohibit their use, provide limitations for their application or at least offer safety advice/ warnings. For example, the use of the pesticide Linuron has been banned in the EU since 2018, among other things because of its carcinogenic properties.1, 2

Up to now, such tests have been performed on rodents. For some time, regulatory authorities, the Industry and academia agreed, that animal testing should be no longer mandatory – primarily because at the time of the beginning of such tests there is already sufficient information available from animal experiments to estimate a possible risk of cancer in humans. However, the corresponding regulation is still not deleted and these tests, which are to a large extent highly stressful for the animal, are continued.

To date, there is no standardized database for replacement methods that provides an overview of all methods, research results and application purposes. This is now changing - the federal government is funding the conceptual development of such a database in a first step until 2021 with 3 million euros.

Today, the 39th Animal Welfare Research Prize of the Federal Ministry of Food and Agriculture (BMEL) was awarded. Dr. Anne-Katrin Rohlfing from the Department of Cardiology and Angiology at the University Hospital of Tübingen was honored for her new method of producing genetically modified platelets for basic research and testing.

Researchers from the Translational Center for Regenerative Therapies at the Fraunhofer Institute for Silicate Research ISC in Würzburg and another team of scientists want to modify a human in vitro cornea model and integrate a measurement technique that does not disturb the processes in the cell culture. With their model, they want to completely replace the eye damage and eye irritation tests on rabbits, which are often very stressful.

For the eighth time, the Lush Prize awarded grants totaling 250,000 pounds on November 11 and 12, 2020. Nadine Dreser from the University of Constance was one of five young international researchers who received £10,000 in funding for her non-animal research project.

Leading cosmetics manufacturers have made a statement against animal testing of cosmetics. This was necessary because a sunscreen manufacturer had been obliged by the European Court of Appeal to carry out animal experiments.

In addition to ACE2, international research teams have found another receptor that the SARS-CoV-2 virus uses to enter the cells: neuropilin-1.

Liver surgery: consultation in silico

Friday, 16 October 2020 13:19

Physicists and scientists from six research institutions in Jena, Berlin, Stuttgart, Bremen as well as Leipzig want to develop a digital model that can mimic the blood flow and function of the healthy and diseased liver in high spatial resolution.

Researchers from Austria have found a way to produce the vaccine adjuvant Squalene in the laboratory, which is, for instance, urgently needed for vaccines against corona. The oil squalene has mainly been extracted from the livers of deep-sea sharks.

Scientists at the University Medical Center Hamburg-Eppendorf (UKE) have discovered that even in the case of simple decisions a large number of regions communicate with each other that are widely distributed over the human brain.