Volunteer study: When the air gets thinner...

Wednesday, 08 December 2021 13:31

Researchers at the University of Duisburg Essen want to investigate how the human immune system reacts to oxygen deficiency and how inflammatory reactions are influenced. For this purpose, they are working with volunteers in an altitude training chamber.

A researcher team from the Department of Experimental Endocrinology at Charité Berlin, together with a researcher from the Federal Institute for Risk Assessment Berlin, has been awarded this year's prize for promoting research into replacement and supplementary methods for animal experiments in research and teaching by the state of Berlin.

Two scientists from the Max Planck Institute for Molecular Biomedicine in Münster are being honored with this year's Animal Welfare Research Award from the German Federal Ministry of Food and Agriculture (BMEL). Scientists Dr. Henrik Renner and Dr. Jan M. Bruder will receive the award for their development of a midbrain on a chip that can be used to conduct toxicity tests and screen active ingredients for drug development.

A research team at the Harvard Wyss Institute for Biologically Inspired Engineering led by Donald Ingber, M.D., Ph.D., has developed a microfluidic organ chip device that is about the size of a USB memory stick, which more accurately reproduces the key pathological features of cystic fibrosis (CF) than other in vitro systems.

Using a self-developed in vitro model, scientists at Saarland University were able to show that the lipid and cholesterol metabolism of tumor-associated immune cells is severely impaired in contrast to that of tumor tissue.

Researchers at the University of Central Florida and at Hesperos, a company based in Orlando, have developed an organ-on-a-chip model to study the mechanisms of the rare autoimmune disease myasthenia gravis.

Dr. Wolfgang Boomgaarden, founder and owner of the Emden-based company PharmaInformatic, has been awarded the Herbert Stiller Prize by the association Doctors Against Animal Experiments.

This year, the Herbert Stiller Prize of the association Doctors Against Animal Experiments goes to Dr. Klara Janjić and her team from the Medical Faculty of the University of Vienna. The researchers have developed a 3D model of the human oral mucosa, which is used to study periodontal disease. However, the model could also help to end animal experiments in dentistry.

Stress research with cerebral organoids

Friday, 29 October 2021 11:21

Scientists at the Max Planck Institute of Psychiatry led by Prof. Dr. Elisabeth Binder have shown that cerebral organoids are a suitable model system to study how stress affects human brain development.

Using cells from patients, researchers at Charité - Universitätsmedizin Berlin, together with scientists from the German Rheumatism Research Center Berlin (DRFZ), have identified an important component in the progression of severe Covid-19 cases. They were able to demonstrate that NK cells, which normally contribute to the early control of SARS-CoV-2, are hindered by the early release of TGFβ.