Researchers at Utrecht University Medical Center have expanded their in vivo research on mice with animal-free methods after receiving support from the 3Rs Centre Utrecht. Suppo3Rt is a staffed central support desk that offers tailored guidance to researchers and other stakeholders about the possibilities of NAMs as a replacement or reduction of animal testing.
The startup LifeTaq from Klosterneuburg, Austria, in collaboration with the Austrian Research Institute for Chemistry and Technology (OFI), has developed a robot-based machine that is capable of producing 3D tissue models fully automatically under controlled conditions. It is intended to replace animal testing in preclinical research.
This year, the animal rights organization Doctors Against Animal Experiments (ÄgT) has awarded Dr. Pedro Caetano Pinto from Greifswald University Hospital the Herbert Stiller Prize for outstanding animal-free research. Dr. Pinto receives the prize, worth €20,000, for his innovative project in which a human bladder-on-a-chip model was developed for research into bladder cancer.
Birds are often overlooked as laboratory animals because they are not used as frequently in experiments as mice, fish, or rats. Nevertheless, many different bird species have to suffer in animal experiments.
The EU Joint Research Center (JRC) is assembling a multidisciplinary group of experts to critically evaluate the current use of animal models as well as the integration of animal-free approaches in cardiovascular research. The work will enable a comprehensive assessment of the scientific, ethical, and practical dimensions of replacing and reducing the use of laboratory animals in this field.
The American company Charles River Laboratories International as well as the Dutch biotechnology company Toxys recently announced their intention to collaborate on the validation of the human stem cell-based in vitro assay ReproTracker. The assay can be used to quickly and reliably identify developmental toxicity risks in new drugs and chemicals without the use of animal testing.
A German-British research team has created the largest genetic map of human metabolism to date, investigating the effects of the human genetic code on blood values such as cholesterol and amino acids. They succeeded in identifying a new gene called VEGFA, which may control aspects of the denser form of cholesterol (HDL). The findings could be of interest for the development of new drugs to prevent heart disease.
The NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) has collaborated with scientists from the German Federal Institute for Risk Assessment (BfR) to develop an application that uses data from the Human Predictive Patch Test (HPPT) to better assess skin sensitization potential when classifying chemicals.
The Johns Hopkins Center for Alternatives to Animal Testing (CAAT) is accepting applications for the 2025 Reduction Grant and the 2025 Humane Education Grant until October 15.
Alzheimer's and dementia are the second greatest fear among Germans after cancer. (1) Despite the approval of antibody therapy for early-stage Alzheimer's, the disease is incurable. New research methods for treating the complex cascade of dramatic nerve cell loss are urgently needed.